Differentiation of Tuberculous and Pyogenic Spondylitis Using Double Phase F-18 FDG PET
Seong-Jang Kim1, 2, Jung Sub Lee*, 2, 3, Kuen Tak Suh2, 3, In-Ju Kim1, 2, Yong-Ki Kim1, 2
Identifiers and Pagination:Year: 2008
First Page: 1
Last Page: 6
Publisher Id: TOMIJ-2-1
Article History:Received Date: 2/11/2007
Revision Received Date: 27/11/2007
Acceptance Date: 11/12/2007
Electronic publication date: 3/1/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
To assess the usefulness of double phase F-18 FDG PET in pyogenic spondylitis (PS) and tuberculous spondylitis (TS). Also, to investigate whether double phase F-18 FDG PET could improve the diagnostic accuracy for discrimination of PS from TS.
Double phase F-18 FDG PET/CT was performed in a consecutive 23 patients (9 men, 14 women; mean age, 58.5±17.9 years, range, 19∼81 years) suspected having spondylitis. PET/CT imaging was performed 60 and 120 minutes after injection of F-18 FDG.
The SUVmax1 of TS and PS showed no statistical differences (TS, 4.53±1.77; PS, 4.5±1.9, p=0.9515). The SUVmax2 also showed no statistical differences between two groups (TS, 5.171.95; PS, 5.3±2.21, p=0.9321). The mean SUV of early and delayed F-18 FDG PET images revealed no statistical differences between TS and PS. The %SUVmax and %SUVmean have no statistical differences between TS and PS (%±SUVmax, TS, 15.07±6.57%, PS, 18.7910.48%, p=0.5109; %±SUVmean, TS, 16.49±9.1%, PS, 16.88±6.72%, p=0.6524). Also, none of these quantitative indices could differentiate the TS from PS. Furthermore, none of these quantitative indices could predict the presence of TS.
Based on the presented data, the quantitative indices of double phase F-18 FDG PET could not differentiate TS from PS despite of high sensitivity for the detection of spondylitis of F-18 FDG PET.