Myocardial Blood-Oxygen-Level-Dependent Magnetic Resonance Imaging with Balanced Steady-State Free Precession Imaging Approaches
Rohan Dharmakumar*, 1, Sotirios A. Tsaftaris2, Debiao Li1
Identifiers and Pagination:Year: 2012
Issue: Suppl 1-M4
First Page: 31
Last Page: 38
Publisher Id: TOMIJ-6-31
Article History:Received Date: 29/12/2010
Revision Received Date: 09/02/2012
Acceptance Date: 13/02/2012
Electronic publication date: 6/4/2012
Collection year: 2012
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The current state of myocardial Blood-Oxygen-Level-Dependent (BOLD) MRI with balanced steady-state free precession (SSFP) approaches is reviewed. Initial studies forming the basis for SSFP-based detection of oxygenation changes beginning with whole blood studies, progressing through controlled studies that consider microcirculatory changes in oxygenation in skeletal muscle and kidney, culminating in basic myocardial studies are outlined. The theoretical basis to observe signal changes and the mechanisms that facilitate such observations are elucidated. Methods to overcome limitations in sensitivity are described.