RESEARCH ARTICLE


Quantifying Myocardial Oxygenation with Cardiac Magnetic Resonance Imaging



David J. Muccigrosso, Jie Zheng*
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

Article Information


Identifiers and Pagination:

Year: 2012
Volume: 6
Issue: Suppl 1-M5
First Page: 39
Last Page: 44
Publisher Id: TOMIJ-6-39
DOI: 10.2174/1874347101206010039

Article History:

Received Date: 29/12/2010
Revision Received Date: 28/12/2011
Acceptance Date: 20/01/2012
Electronic publication date: 6/4/2012
Collection year: 2012

© 2012 Muccigrosso and Zheng

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Cardiovascular Imaging Lab, 510 South Kingshighway Blvd., Campus Box 8225, St. Louis, MO 63110, USA; Tel: (314) 747-4608; Fax: (314) 747-3882; E-mail: zhengj@mir.wustl.edu


Abstract

Myocardial ischemia, resulting from imbalance in myocardial oxygen supply and demand, can be quantitatively assessed by positron emission tomography (PET) with absolute measures of myocardial blood flow and oxygen consumption rate (MVO2). Cardiac Magnetic Resonance (CMR) has notable advantages over PET, with no radiation, high spatial resolution, faster scan times, and excellent soft tissue contrast. We have developed and validated new quantitative CMR oximetry techniques, including measurements of hyperemic myocardial oxygen extraction fraction and MVO2 through Fick's Law. These may lead to a new understanding of roles of myocardial microcirculation in myocardial ischemia. Other cardiac oximetry methods for directly quantifying MVO2 with 17O-labelled water are also under investigation. Quantitative CMR oximetry is a promising, non-invasive, non-radiation approach for exploring the myocardial metabolism's role in cardiac patients.

Keywords: Magnetic resonance imaging, ischemia, oxygen extraction, oxygen consumption.