Primary Central Nervous System Lymphoma with Lateral Ventricle Involvement

Yumi Oie1, *, Kazuhiro Murayama1, Shinya Nagahisa2, Masato Abe3, Hiroshi Toyama1, Kazuhiro Katada1
1 Department of Radiology, Fujita Health University, Japan
2 Department of Neurosurgery, Fujita Health University, Japan
3 Department of Pathology, Fujita Health University, Japan

© 2012 Oie et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the 1-98, Dengakugakubo, Kutsukake, Toyoake, Aichi 470-1192, Department of Radiology, Fujita Health University, Japan; Tel: 81-562-93-9259; Fax:81-562-95-2253; E-mail:


A 77-year-old woman presented with worsening cognitive impairment, nausea and vomiting. Computed tomography (CT) of the head revealed a high-density mass that symmetrically filled both lateral ventricles. Magnetic resonance imaging (MRI) showed an enhanced mass with T1 and T2 prolongation and restricted diffusion on diffusion weighted imaging (DWI). Diagnosis was delayed until a post-mortem examination, which revealed the mass as a primary central nervous system lymphoma (PCNSL). A high-intensity tumor on DWI with lateral ventricle involvement should raise the possibility of PCNSL.

Keywords: Primary central nervous system lymphoma (PCNSL), Magnetic resonance imaging (MRI), Diffusion weighted image (DWI), Magnetic resonance spectroscopy (MRS), Intraventricular tumor.